Tumor Mutation Burden and Differentially Mutated Genes Among Immune Phenotypes in Patients with Lung Adenocarcinoma
Hao Wang 1 2, Shanhao Chen 1, Die Meng 1 2, Chunyan Wu 3, Junjie Zhu 4, Minlin Jiang 1 2, Jing Ning 1 2, Shengyu Wu 1 2, Lijia Wu 5, Jingjie Li 5, Bin Chen 1, Sha Zhao 1, Wei Li 1, Jia Yu 1 2, Qiyu Fang 1 2, Jun Zhu 1 2, Wencheng Zhao 1 2, Yayi He 1, Caic

Low TMB level could be the reason for the poor efficacy of ICBs in patients having EGFR mutation. And mutational frequencies of KRAS and BRCA2 were lower in EGFR-mutant patients. Furthermore, ALK, CDKN2A, MAP2K1, IDH2 and PTEN might involve in the formation of immune phenotypes.

Onco Targets Ther. 2021 May 4;14:2953-2965.

Discrepancy in p16 expression in patients with HPV-associated head and neck squamous cell carcinoma in Thailand: clinical characteristics and survival outcomes
Lalida Arsa 1, Teerada Siripoon 2, Narumol Trachu 3, Sasithorn Foyhirun 4, Duangjai Pangpunyakulchai 4, Suda Sanpapant 4, Natini Jinawath 5 6 7, Poompis Pattaranutaporn 8, Artit Jinawath 1, Nuttapong Ngamphaiboon

Low prevalence of p16 and HPV associated OPSCC and non-OPSCC were confirmed in Thai patients. High discordance and low positive predictive rates of p16 were observed in HPV-associated OPSCC. p16 was a significant prognostic factor for OS for patients with OPSCC or non-OPSCC. Therefore, HPV testing should be performed to assess the association of HPV with HNSCC regardless of p16 expression.

BMC Cancer. 2021 May 6;21(1):504. 

MRI Radiomics Signature as a Potential Biomarker for Predicting KRAS Status in Locally Advanced Rectal Cancer Patients
ZhiYuan Zhang 1 2 3, LiJun Shen 1 2 3, Yan Wang 1 2 3, Jiazhou Wang 1 2 3, Hui Zhang 1 2 3, Fan Xia 1 2 3, JueFeng Wan 1 2 3, Zhen Zhang

Front Oncol. 2021 May 7;11:614052. 

Development of an optimal protocol for molecular profiling of tumor cells in pleural effusions at single‐cell level
Ikuko Takeda Nakamura 1 2, Masachika Ikegami 1 3, Nobuhiko Hasegawa 1 4, Takuo Hayashi 5, Toshihide Ueno 1, Masahito Kawazu 1, Shigehiro Yagishita 6, Yasushi Goto 7, Yuki Shinno 7, Yuki Kojima 8, Kazuya Takamochi 9, Fumiyuki Takahashi 2, Kazuhisa Takahash

This protocol is applicable to circulating tumor cells analysis of peripheral blood and expands the possibility of utilizing molecular profiling of cancers.

Cancer Sci. 2021 May;112(5):2006-2019. 

Genetic Analysis and Operative Outcomes in Patients with Oncogene-Driven Advanced NSCLC Treated with Cytoreductive Surgery as a Component of Local Consolidative Therapy
"Byung Jo Park 1,? , Hyo Sup Shim 2,? , Chang Young Lee 1 , Jin Gu Lee 1, Hye Ryun Kim 3, Sang Hoon Lee 4, Min Hee Hong 3,* and Seong Yong Park"

We conclude that pulmonary resection for advanced NSCLC after targeted therapy is feasible, and the surgical specimens could be used for planning further targeted therapy.

Cancers 2021, 13(11), 2549

Homologous Recombination Repair Gene Mutations in Chinese Localized and Locally Advanced Prostate Cancer Patients
Xingran Jiang 1, Xiumei Hu 2, Yajuan Gu 3, Yunlong Li 4, Mulan Jin 5, Hongying Zhao 6, Ruixia Gao 7, Zhan Huang 8, Jun Lu 9

This study illustrated the mutation patterns of HRR genes in Chinese population with localized and locally advanced prostate cancer. These results provide further evidence that HRR gene mutations were more prevalent in patients with higher Gleason grade, or with very-high-risk level. Patients with these clinicopathologic characteristics may need more precise stratification through molecular detection.

"Pathol Res Pract. 2021 May 29;224:153507."

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